Our scientific endeavors increasingly involve collaborations both on and off the UW–Madison campus. Such collaborations include studies of HIV, influenza virus, and tumor viruses such as hepatitis B virus, Epstein Barr virus and human papillomavirus. Collaborations are also critical to secure access to large collections of patient specimens and accompanying medical and demographic information, to carry out an array of human genome-wide molecular analyses on virus-associated cancers, and to meaningfully integrate the resulting multiple extensive datasets. The goal is to identify molecular signatures of virus-infections and associated disease that can be exploited to derive new targets for disease prevention, diagnosis, prognosis, and treatment intervention.